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It is not clear why the parasites transfer and utilize iron using hemozoin, but it is likely that when erythrocytes are degraded and utilized to form iron-containing heme crystals in situ , few free heme are released to the outside of the cells, as suggested by the colorless supernatant of the Schistosoma gut content after centrifugation

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Therefore, early interventions targeting neuroregenerative mechanisms before the collapse of neurogenic potential may offer maximal therapeutic promise